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pentobarbital will lower the level or influence of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.Use with caution in Expecting Gals and youngsters down below 3 many years of age. P